Pharmaceutical Organic Chemistry-III

Table of Content

1. Stereo isomerism
2. Optical isomerism – Optical activity, enantiomerism, diastereoisomerism, meso compounds Elements of symmetry, chiral and achiral molecules
3. DL system of nomenclature of optical isomers, sequence rules, RS system of nomenclature of optical isomers
4. Reactions of chiral molecules
5. Racemic modification and resolution of racemic mixture.
6. Asymmetric synthesis: partial and absolute
7. Geometrical isomerism
8. Nomenclature of geometrical isomers (Cis-Trans, E-Z, Syn-Anti systems)
9. Methods of determination of configuration of geometrical isomers.
10. Conformational isomerism in Ethane, n-Butane and Cyclohexane.
11. Stereo isomerism in biphenyl compounds (Atropisomerism) and conditions for optical activity.
12. Stereospecific and stereoselective reactions
13. Heterocyclic compounds:
14. Nomenclature and classification
15. Synthesis, reactions and medicinal uses of following compounds/derivatives Pyrrole, Furan, and Thiophene
16. Relative aromaticity and reactivity of Pyrrole, Furan and Thiophene
17. Synthesis, reactions and medicinal uses of following compounds/derivatives
18. Pyrazole, Imidazole, Oxazole and Thiazole.
19. Pyridine, Quinoline, Isoquinoline, Acridine and Indole. Basicity of pyridine
20. Synthesis and medicinal uses of Pyrimidine, Purine, azepines and their derivatives
21. Reactions of synthetic importance
22. Metal hydride reduction (NaBH4and LiAlH4), Clemmensen reduction, Birch reduction, Wolff Kishner reduction.
23. Oppenauer-oxidation and Dakin reaction.
24. Beckmanns rearrangement and Schmidt rearrangement.
25. Claisen-Schmidt condensation.