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Pharmaceutical Chemistry (Bilingual) D.Pharm 1st Year Text Book

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Pharmaceutical (Medicinal) chemistry is concerned with the design (drug design) and synthesis of biologically active molecules. The aim is to gain new chemical molecules that could enable the discovery of new pharmaceuticals or optimize already known drug structures, thereby to expand the portfolio of chemical drugs. Although organic chemistry plays a crucial role, only knowledgeable pharmaceutical chemists are able to work effectively in a highly interdisciplinary environment and interact with scientists in other disciplines, such as molecular biology, structural biology, pharmacology, physical chemistry, biochemistry, pharmacokinetics, pharmaceutical technology, toxicology or with experts from the field of translational medicine, etc. This book is written with very easy language in English as well as Hindi. The textbook second part includes practical exercises where a student could apply his or her theoretical concepts to real practical situations.

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ISBN 978-81-19781-71-3
Publishers R. Narain Publishers & Distributors
Author Dr. Mohit Gupta, Dr. Sameer Rastogi, Dr. Rita Mourya & Rachana
Binding Paperback
Edition 1/e
Price 320
Year 2024
Pages 256
Subject Bilingual Text Book of Pharmaceutical Chemistry
Weight 250 g
Dimensions 24 × 19 × 1 cm

Table of Content

CHAPTER – 1

      Introduction to Pharmaceutical chemistry: Scope and objectives

      Sources and types of errors: Accuracy, precision, significant figures.

      Impurities in Pharmaceuticals: Source and effect of impurities in pharmacopoeial substances, importance of limit test, Principle and procedures of Limit tests for chlorides, sulphates, iron, heavy metals and arsenic.

CHAPTER – 2

      Volumetric analysis: Fundamentals of volumetric analysis, Acid-base titration, Non-aqueous titration, precipitation titration, complexometric titration, redox titration

      Gravimetric analysis: Principle and method.

CHAPTER – 3

      Inorganic Pharmaceuticals: Pharmaceutical formulations, storage conditions and uses of

l    Haematinics: Ferrous sulphate, Ferrous gluconate

l    Antacids: Aluminium hydroxide gel, Magnesium hydroxide

l    Anti microbial agents: Hydrogen peroxide, Boric acid, Bleaching powder

l    Dental products: Calcium carbonate, Sodium fluoride

l    Medicinal gases: Carbon dioxide, nitrous oxide, oxygen

CHAPTER – 4

Introduction to nomenclature of organic chemical systems with particular reference to heterocyclic compounds containing up to Three rings.

      Study of the following category of medicinal compounds with respect to classification, chemical name, chemical structure (compounds marked with*) uses, stability and storage conditions, different types of formulations and their popular brand names

CHAPTER – 5

Drugs acting on Central Nervous System

l    Anaesthetics: Thiopental sodium*, Ketamine hydrochloride*.

l    Sedatives and Hypnotics: Diazepam*, Alprazolam*, Nitrazepam, Phenobarbital*.

l    Antipsychotics: Chloropromazine hydrochloride*, Haloperidol*, Droperidol, Risperidone*, Sulperide*

l    Anticonvulsants: Phenytoin*, Ethosuximide, Carbamazepine*, Clonazepam, Primidone, Valproic acid*, Gabapentin*

l Anti-depressants: Amitriptyline hydrochloride*, Imipramine hydrochloride*, Fluoxetine*.

CHAPTER – 6

Drugs acting on Autonomic Nervous System

l    Sympathomimetic agents: Direct acting: Nor-epinephrine, Epinephrine, Phenylephrine, Dopamine, Terbutaline, Salmeterol, Salbutamol, Albuterol, Naphazoline, Tetrahydrazoline, Oxymetazoline.

l    Indirect acting agents: Hydroxyamphetamine, Pseudoephedrine, Propylhexadrine.

l    Agents with mixed mechanism: Ephedrine, Metaraminol.

l    Adrenergic Antagonists: Alpha adrenergic blockers: Tolazoline, Phentolamine, Phenoxybenzamine, Prazosin, Doxazosin.

l    Beta adrenergic blockers: Propranolol, Practolol, Acebutolol, Atenolol, Esmolol, Metoprolol, Labetolol and Carvedilol

l    Cholinergic drugs and related agents: Direct acting agents: Acetylcholine, Carbachol, Bethanechol, Methacholine and Pilocarpine.

l    Cholinesterase inhibitors: Neostigmine, Pyridostigmine, Edrophonium chloride, Tacrine hydrochloride, Ambinonium chloride, Pralidoxime chloride, Isofluorphate, Echothiophate iodide, Parathione, Malathion.

l    Cholinergic Blocking agents: Solanaceous alkaloids and analogues: Atropine sulphate, Homatropine hydrogen bromide, Ipratropium bromide.

l    Synthetic cholinergic blocking agents: Tropicamide, Cyclopentolate hydrochloride, Clindinium bromide, Dicyclomine hydrochloride, Procylidine hydrochloride Tridihex ethylchloride, Isopropamide iodide, and Ethopropazine hydrochloride

CHAPTER – 7

Drugs acting on Cardiovascular System

l    Anti-arrythmic Drugs: Quinidine sulphate, Procainamide hydrochloride, Verapamil, Diltiazem hydrochloride, Phenytoin sodium, Lidocaine hydrochloride, Tocainide hydrochloride, Mexiletine hydrochloride, Lorcainide hydrochloride, amiodarone and Sotalol.

l    Anti-hypertensive Agents: Propranolol, timolol, Captopril, Lisinopril, Enalapril, Benzapril hydrochloride, Quinapril hydrochloride, Methyldopate hydrochloride, Clonidine hydrochloride. Reserpine, Hydralazine hydrochloride, Nifedipine,

l    Antianginal agents: isosorbide dinitrate, amyl nitrite

CHAPTER – 8

      Diuretics: acetazolamide, frusemide, bumetanide, chlorthiazide, benzthiazide, xipmide, spiranolactone

CHAPTER – 9

      Hypoglycemic agents: insulin and its preparations, metformin, tolbutamide, glibenclamide, glipizide, Glimepiride, pioglitazone, ripaglinide

CHAPTER – 10

      Analgesic and anti-inflammatory agents: Morphine analogues, Narcotic antagonists; Nonsteroidal anti inflammatory agents (NSAIDs) aspirin, diclofenac, ibuprofen, piroxicam, celecoxib, mefenamic acid, paracetamol.

CHAPTER – 11

Anti-infective agents

l    Antifungal agents: Amphotericin-B and Griseofulvin, Econoazole nitrate, Miconazole, Ketoconazole, Itraconazole, Fluconazole, Naftifine hydrochloride, Tolnaftate.

l    Urinary tract anti-infective agents: Nalidixic Acid, Cinoxacin, Norfloxacin, Ciprofloxacin, Ofloxacin, Lomefloxacin, Sparfloxacin.

l    Anti-tubercular Agents: INH, Ethionamide, ethambutol, Pyrazinamide, Para amino salicylic acid, Rifampicin

l    Antiviral agents: Amantadine hydrochloride, Idoxuridine, Acyclovir, Gancyclovir, Foscarnet, Zidovudine, Lamivudine, Ribavirin

l    Antimalarials: Quinine sulphate, Chloroquine phosphate, Primaquine phosphate, Quinacrine hydrochloride, Mefloquine, Cycloguanil , proguanil, Pyrimethamine

l    Sulfonamides: History and development, mechanism of action sulfanilamide, sulfadiazine, sulfamethoxazole, sulfacetamide, mefenide acetate and cotrimoxazole

CHAPTER – 12

      Antibiotics: Penicillin G, ampicillin, amoxicillin, cloxacillin, clavulanic acid, cephalosporins, streptomycin, neomycin, tetracycline, doxycycline, minocycline, erythromycin, azithromycin, chloramphenicol, clindamycin.

CHAPTER – 13

      Anti-neoplastic agents: Meclorethamine, Cyclophosphamide, Busulfan, Thiotepa, Mercaptopurine, Fluorouracil, Floxuridine, Cytarabine, Methotrexate, Azathioprine, Dactinomycin, Daunorubicin hydrochloride, Doxorubicin hydrochloride, Etoposide, Vinblastin sulphate, Vincristin sulphate, Cisplatin, Mitotane and bromostanolone propionate.

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