Historical perspective of immune system and immunity, Innate and specific immunity, The organs and cells of the immune system.
Antibody structure in relation of function and antigen-binding: Types of antibodies and their structures, isotypes, allotypes, idiotypes.
Measurement of antigen: antibody interaction, agglutination, immunodiffusion, immuno-electrophoresis, ELISA, RIA, production of monoclonal antibodies.
Histocompatibility: structure of MIIC class I, II & III antigens & their mode of antigen presentation, MIIC restriction; antigens & antigenicity.
Humoral immunity and clonal selection theory;
Immunoglobulin gene: Genetic basis of creation of antibody diversity, Effect of T cell functions.
Immunity of infection of diseases: Vaccine, (attenuated and recombinant) and vaccination.
Antibodics in targeting therapeutic agents;
Autoimmunity: Mechanism of autoimmune diseases (Hashimoto’s thyroditis, myasthenia gravis; Rheumatoid arthritis, pernicious anemia Asthma).